Exploring quercetin's potential to counteract intestinal pro-inflammatory effects induced by silver nanoparticles

Authors

  • Adelaide Sousa LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal
  • Rui Azevedo LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal
  • Vera M. Costa UCIBIO, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050‑313 Porto, Portugal; Associated Laboratory i4HB – Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313, Porto, Portugal
  • Sara Oliveira Coimbra Institute of Clinical and Biomedical Research (iCBR), Faculty of Medicine and Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548
  • Sofia Viana Coimbra Institute of Clinical and Biomedical Research (iCBR), Faculty of Medicine and Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal; Clinical Academic Center of Coimbra, 3004-531 Coimbra, Portugal; Instituto Politécnico de Coimbra, Coimbra Health School (ESTeSC), 3046-854 Coimbra, Portugal
  • Flávio Reis Coimbra Institute of Clinical and Biomedical Research (iCBR), Faculty of Medicine and Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal; Clinical Academic Center of Coimbra, 3004-531 Coimbra, Portugal
  • Agostinho Almeida LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal
  • Paulo Matafome Coimbra Institute of Clinical and Biomedical Research (iCBR), Faculty of Medicine and Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal; Clinical Academic Center of Coimbra, 3004-531 Coimbra, Portugal; Instituto Politécnico de Coimbra, Coimbra Health School (ESTeSC), 3046-854 Coimbra, Portugal
  • Patrícia Dias-Pereira ICBAS School of Medicine and Biomedical Sciences, University of Porto (ICBAS-UP),4050-313, Porto, Portugal
  • Félix Carvalho UCIBIO, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050‑313 Porto, Portugal; Associated Laboratory i4HB – Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313, Porto, Portugal
  • Eduarda Fernandes LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal
  • Marisa Freitas LAQV, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal https://orcid.org/0000-0001-9114-9967

DOI:

https://doi.org/10.48797/sl.2024.240

Keywords:

Poster

Abstract

Background: Silver nanoparticles (AgNP) elicit an intestinal response characterized by vascular and cellular changes, alongside the release of cytokines linked to the activation of the nuclear factor-кB (NF-кB) pathway. Consequently, a search was conducted for a compound capable of counteracting the primary pro-inflammatory effects induced by these nanoparticles [1]. Given the reported anti-inflammatory properties of quercetin and its prevalence in the human diet, the use of this compound could be considered a potential strategy for safeguarding the body against the harmful effects of AgNP [2]. Objective: Evaluate the potential protective role of quercetin against the pro-inflammatory effects induced by 5 nm polyvinylpyrrolidone (PVP)-AgNP in C57BL/6J mice. Methods: Two subacute doses of 5 nm PVP-AgNP were orally administered once daily for 14 days using a novel dosing technology (HaPILLness), facilitating stress-free, precise oral dosing. Quercetin (1 mg/kg bw) was concurrently administered via intraperitoneal injection once daily for the same 14-day period. Results: Our findings revealed that quercetin effectively reduced the intestinal inflammatory response caused by AgNP, through a reduction of the vascular and cellular alterations and also a tight regulation of the major NF-кB inflammatory pathway, leading to a notable decrease in cytokine production. Conclusions: This study provides novel insights into the potential role of quercetin in alleviating the intestinal pro-inflammatory effects induced by 5 nm PVP-AgNP.

References

1. Sousa, R. Azevedo, V. M. Costa, S. Oliveira, I. Preguiça, S. Viana, F. Reis, A. Almeida, P. Matafome, P. Dias Pereira, F. Carvalho, E. Fernandes, M. Freitas, Archives of Toxicology, 97 (2023) 2643.

2. I. Shabir, V. Kumar Pandey, R. Shams, A. H. Dar, K. K. Dash, S. A. Khan, I. Bashir, G. Jeevarathinam, A. V. Rusu, T. Esatbeyoglu, R. Pandiselvam, Frontiers in Nutrition, 9 (2022) 999752.

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Published

2024-05-01

How to Cite

Sousa, A., Azevedo, R., Costa, V. M., Oliveira, S., Viana, S., Reis, F., Almeida, A., Matafome, P., Dias-Pereira, P., Carvalho, F., Fernandes, E., & Freitas, M. (2024). Exploring quercetin’s potential to counteract intestinal pro-inflammatory effects induced by silver nanoparticles. Scientific Letters, 1(Sup 1). https://doi.org/10.48797/sl.2024.240

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