Chronic exposure to the synthetic cathinone 3,4-methylenedioxypyrovalerone (MDPV) reveals enantioselective effects in Daphnia reproduction
DOI:
https://doi.org/10.48797/sl.2024.215Keywords:
PosterAbstract
Background: The abuse of synthetic cathinones (SC) is popular among young consumers for recreational purposes and has increased dramatically in the last years. Consequently, SC have been found in the aquatic environment at low concentrations [1]. Since SC are designed to change nervous system function, they may pose unpredictable harmful effects on non-target organisms, such as aquatic invertebrates [2]. Many SC, like 3,4-methylenedioxypyrovalerone (MDPV), are chiral, and therefore may exhibit enantioselectivity including in ecotoxicity [2,3]. Considering the limited information available on MDPV ecotoxicity and enantioselectivity, it is vital to assess its potentially enantioselective effects on aquatic organisms. Objective: This work aimed to assess the adverse effects of (R,S)-MDPV, (R)-MDPV, and (S)-MDPV on the survival, body size and reproduction of Daphnia magna after 21 days of chronic exposure. Methods: Daphnia neonates (< 24 hours) were individually exposed to concentrations ranging between 0.10 to 1.79 µg L‒1 of (R,S)-MDPV, (R)-MDPV and (S)-MDPV for 21 days, using 10 organisms per concentration. Survival and reproduction data were recorded every day until day 21, whereas body size was determined at day 7 in a random subsample of 5 individuals per concentration (using microphotography analysis with ImageJ). Results: Chronic assays showed significant inhibition of the population rate of increase at 1.79 µg L‒1 and reproductive output (number of offspring per female) at 1.00 and 1.79 µg L‒1, only for (R)-MDPV. Although (R,S)-MDPV and both enantiomers did not cause significant effects in mortality, it should be noted that organisms exposed to (R)-MDPV showed a slight decrease in survival at 1.00 and 1.79 µg L‒1 when compared to the control. Conclusions: The present study demonstrated that chronic exposure to MDPV can impair D. magna reproduction, with (R)-MDPV causing adverse chronic effects at the tested concentrations, unlike the (S)-enantiomer and (R,S)-MDPV.
References
1. Castiglioni, S.; Salgueiro-González, N.; Bijlsma, L.; Celma, A.; Gracia-Lor, E.; Beldean-Galea, M.; Mackuľak, T.; Emke, E.; Heath, E.; Kasprzyk-Hordern, B.; Petkovic, A.; Poretti, F.; Rangelov, J.; Santos, M.; Sremacki, M.; Styszko, K.; Hernández, F.; Zuccato, E. New psychoactive substances in several European populations assessed by wastewater-based epidemiology. Water Res (2021), 195, 116983.
2. Kuropka, P.; Zawadzki, M.; Szpot, P. A review of synthetic cathinones emerging in recent years (2019–2022). Forensic Toxicol (2022), 41(1), 25-46.
3. Pérez-Pereira, A.; Ribeiro, C.; Teles, F.; Gonçalves, R.; Goncalves, V.; Pereira, J.; Carrola, J.; Pires, C.; Tiritan, M. Ketamine and norketamine: enantioresolution and enantioselective aquatic ecotoxicity studies. Environ Toxicol Chem (2021), 41(3), 569-579.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Ariana Pérez-Pereira, Pedro A. Costa, Bruno B. Castro, João S. Carrola, Virgínia M. F. Gonçalves, Ana R. L. Ribeiro, Carla Fernandes, Maria E. Tiritan, Cláudia Ribeiro
This work is licensed under a Creative Commons Attribution 4.0 International License.
In Scientific Letters, articles are published under a CC-BY license (Creative Commons Attribution 4.0 International License), the most open license available. The users can share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material for any purpose, even commercially), as long as they give appropriate credit, provide a link to the license, and indicate if changes were made (read the full text of the license terms and conditions of use).
The author is the owner of the copyright.
